2 edition of Heterogeneity of presynaptic alpha-adrenoceptors in rat atria. found in the catalog.
Heterogeneity of presynaptic alpha-adrenoceptors in rat atria.
Christine F. Dutta
Thesis (Ph.D.) - Portsmouth Polytechnic, 1983.
Alpha(2A)-adrenergic receptors are primarily presynaptic heteroreceptors in the C1 area of the rat rostral ventrolateral medulla Teresa A. Milner, Diane L. Rosin, Amy Lee, Sue Aicher Research output: Contribution to journal › Article. In rat aorta, D (10(-8) to 10(-5) M) effectively and concentration-dependently reduced the maximal responses to St , clonidine and Sgd /75 (maximal percentage inhibition 84 +/- ,
The function of presynaptic autoreceptors was studied in the hippocampus, occipito-parietal cortex, atria and vas deferens of NMRI mice, mice in which the A/D-, the B- or C. James R. Docherty, An investigation of presynaptic α‐adrenoceptor subtypes in the pithed rat heart and in the rat isolated vas deferens, British Journal of Pharmacology, /jtbx, 82, 1, (), ().
The binding of (-) [3H]quinuclidinylbenzilate (QNB), a potent muscarinic antagonist, to cardiac muscarinic receptors was examined in washed particles and microsomes isolated from rat heart atria. 2. They demonstrated that in rat atria the ability of isoproterenol to enhance impulse-evoked efflux of norepinephrine at 2 Hz was inversely related to the degree of activation of presynaptic a2-adrenoceptors under the following 3 conditions: the presence MISU AND KUBO of norepinephrine, the presence of phentolamine and the absence of either drug.
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Abstract. The pharmacological properties of presynaptic alpha 2-autoreceptors were studied in rat isolated submaxillary glands and atria. Tissue pieces were preincubated with [3H]-noradrenaline, then superfused with medium containing desipramine, and stimulated electrically.
Kobinger W, Pichler L. Investigation into different types of post- and presynaptic alpha-adrenoceptors at cardiovascular sites in rats.
Eur J Pharmacol. Aug 8; 65 (4)– Ledda F, Mantelli L. Differences between the prejunctional effects of phenylephrine and clonidine in guinea-pig isolated atria Cited by: Majewski H, Rand MJ.
An interaction between prejunctional alpha-adrenoceptors and prejunctional beta-adrenoceptors. Eur J Pharmacol. Feb 19; 69 (4)– Majewski H, Rand MJ, Tung LH. Activation of prejunctional beta-adrenoceptors in rat atria by adrenaline applied exogenously or released as a co-transmitter.
Br J by: Heterogeneity of presynaptic alpha-adrenoceptors in rat atria Author: Dutta, C. ISNI: X Awarding Body: Council for National Academic Awards Current Institution: Open University Date of Award: Availability of Full Text.
The effects of a wide range of PGE1 and PGE2 concentrations on the isometric developed tension of isolated rat atria beating spontaneously or paced at Cited by: The presynaptic α-adrenoceptors mediating inhibition of K +-induced release of [3 H]noradrenaline (NA) from superfused slices and synaptosomes obtained from the nucleus tractus solitarii (NTS) region were characterized pharmacologically and compared to those in the cerebral cortex.
Clonidine concentration-dependently (pD 2 ) reduced the K +-induced [3 H]NA release. Doxey, J. and Roach, A.
() Presynaptic alpha-adrenoceptors; in vitro methods and preparations utilized in the evaluation of agonists and antagonists. Auton. Pharmacol. 1, 73– PubMed CrossRef Google Scholar.
The best example of this heterogeneity is the differences in the pharmacologic properties of alpha-2 receptors in rodent and non-rodent mammalian species. Prazosin generally has a high affinity for rodent alpha-2 receptors, but a low affinity for non-rodent alpha-2 receptors, while oxymetazoline is more potent at non-rodent alpha-2 receptors.
Docherty JR, McGrath JC ( b) An examination of factors influencing adrenergic transmission in the pithed rat, with special reference to noradrenaline uptake mechanisms and post-junctional alpha-adrenoceptors.
Naunyn Schmiedebergs Arch Pharmacol – Google Scholar. The object of this study was to determine suitable experimental conditions for the pharmacological evaluation of cardiac alpha-adrenoceptors.
Atrial and ventricular preparations of the guinea pig and rat were employed, and the alphaadrenoceptor responsiveness was compared with the binding of the alpha-adrenoceptor radioligand [3 H]prazosin in membranes prepared from these.
Exogenous NA strongly inhibited [ 3 H]NA release from cortex slices of newborn rats, indicating that presynaptic α-receptors exist already on the day of birth. In fact, at least up to and including the 17th day after birth, NA caused a stronger inhibition of [ 3 H]NA release from neonatal than from adult cortex slices.
Abstract. 1 The relation of calcium ion influx into nerve terminals to presynaptic adrenoceptor function and the possible masking, by desensitization due to intraneuronal calcium accumulation, of the effects of adrenoceptor agonists and antagonists on presynaptic α-adrenoceptors was investigated in guinea-pig atria previously incubated with [3 H]-noradrenaline.
Hermann Fuder, Erich Muscholl, Romeo Spemann, The determination of presynaptic pA2 values of yohimbine and phentolamine on the perfused rat heart under conditions of negligible autoinhibition, British Journal of Pharmacology, /jtbx, 79, 1, (), (). Summary. Fifteen days after duct ligation, the wet weight of the rat submaxillary gland was reduced to 40% of the contralateral control.
Under these experimental conditions, the noradrenaline (NA) content expressed as μg/g was ± in the control glands and ± in the atrophied glands. Stevens MJ, Moulds RF. Heterogeneity of post-junctional alpha-adrenoceptors in human vascular smooth muscle.
Arch Int Pharmacodyn Ther. Nov; (1)– [Google Scholar] Sullivan AT, Drew GM. Pharmacological characterisation of pre- and postsynaptic alpha-adrenoceptors in dog saphenous vein. Naunyn Schmiedebergs Arch Pharmacol.
The effects of FLA [4-amino(2,6-dichlorobenzylidenehydrazino)-1,2,4-triazol] on blood pressure and heart rate in anaesthetized, normotensive rats, stimulation-induced tachycardia in pithed rats and sedation in mice were studied.
Following intravenous administration to anaesthetized normotensive rats FLA caused a dose-dependent decrease in mean arterial pressure accompanied by.
Abstract. 1 Changes in mean arterial pressure, heart rate and plasma noradrenaline after alpha-adrenoceptor blockade with several alpha-adrenoceptor antagonists have been studied in the conscious rabbit in order to investigate the possible role of presynaptic alpha-adrenoceptors in cardiovascular regulation.
2 Prazosin ( mg/kg) and phentolamine ( mg/kg) produced dose-dependent. nerves is set bypresynaptic inhibitory receptors re-sponsiveto the free synapticconcentrationofprevi-ously released neurotransmitter is widely accepted (see review by Starke, ).
Feedback regulation seemedto providethe explanationfor the observed enhancement of stimulation-induced efflux by ad-renoceptorantagonistsandits inhibitionbyagonists.
The antagonists displaced [3H]-rauwolscine from rat brain and rabbit spleen membranes but there were substantial differences in rank order and absolute potency in the two tissues.
pA2 values for yohimbine, phentolamine and Wy against the selective alpha 2 agonist UK, were determined in the rat left atrium, rat and rabbit vas deferens. Joseph G. Cannon's research works with 2, citations and 1, reads, including: Book Review of A History of Medicinal Chemistry A History of Medicinal Chemistry.
By William A. Remers. Characterization of presynaptic alpha-2 adrenoceptors in rat brain.After the loading of incubated, homogeneously innervated tissues with 3H-noradrenaline (monoamine oxidase and catechol-O-methyl transferase inhibited, calcium-containing solution) high K+ released the 3H-amine from adrenergic varicosities.
In paired experiments the sensitivity of rat atria to high K+ exceeded that of vasa deferentia. In the rat vas deferens the releasing effect of high K+ was.PubMed:Different alpha-adrenoceptors modulate the release of 5-hydroxytryptamine and noradrenaline in rat cortex.
PubMed:alpha 2-Adrenoceptor agonists induced mydriasis in the rat by an action within the central nervous system. PubMed:An electrophysiological study of presynaptic alpha-adrenoceptors in the vas deferens of the mouse.